- The ability of a particular substance to provoke an immune response.
Immunogenicity is the ability of a particular substance, which is called the antigen, to provoke an immune response.
The ability of antigen to elicit immune response is called “Immunogenicity”.
Antigens that do provoke the immune response are called-”immunogens”
Immunogenic potency of antigens
Lipids, nucleic acids serve as immunogens only when they are in combination with proteins/polysaccharides.
-For studies of humoral immune response – proteins/ polysaccharides are used
-For cell-mediated immunity – only proteins serve as immunogens
Factors influencing immunogenicity
->Contribution of antigen to immunogenicity
->Contribution of biological system to immunogenicity
Antigens and immunogenicity
see the diagram
Immunogenicity is influenced by multiple characteristics of an antigen:
-Foreignness: Phylogenetic distance
-Chemical composition and heterogeneity
-Degradability (ability to be processed & presented to T cells)
immunogenicity in German: Immunogenität